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Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30, Stockholm, Sweden.
Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30, Stockholm, Sweden.
Berlin, Germany; London, UK.
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2015 (English)In: Neuropsychology Review, ISSN 1040-7308, E-ISSN 1573-6660, Vol. 25, no 1, 47-62 p.Article, review/survey (Refereed) Published
Abstract [en]

Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 25, no 1, 47-62 p.
Keyword [en]
Aging, Functional brain imaging, Cognition, Genetics, APOE, BDNF, COMT, KIBRA
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:umu:diva-103168DOI: 10.1007/s11065-015-9279-8ISI: 000352822500004PubMedID: 25666727OAI: oai:DiVA.org:umu-103168DiVA: diva2:815241
Available from: 2015-05-29 Created: 2015-05-18 Last updated: 2017-12-04Bibliographically approved

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