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Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease
Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
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2014 (English)In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 22, no 11, 1774-1783 p., 25106677Article, review/survey (Refereed) Published
Abstract [en]

Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, northern-east to southern-west belt in China and North Korea. In 1990's, it was estimated that in China 1–3 million people had some degree of symptoms of the disease, although even higher estimates have been presented. In China, the extensive prevalence peaked in the late 1950's, but since then, in contrast to the global trend of the osteoarthritis (OA), the number of cases has been dramatically falling. Up to 2013, there are 0.64 millions patients with the KBD and 1.16 millions at risk in 377 counties of 13 provinces or autonomous regions. This is obviously thanks to the preventive efforts carried out, which include providing millions of people with dietary supplements and clean water, as well as relocation of whole villages in China. However, relatively little is known about the molecular mechanisms behind the cartilage damage, the genetic and the environmental risk factors, and the rationale of the preventive effects. During the last decade, new data on a cellular and molecular level has begun to accumulate, which hopefully will uncover the grounds of the disease.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 22, no 11, 1774-1783 p., 25106677
Keyword [en]
Kashin-Beck disease, cartilage, osteochondropathy, gene expression, proteomics
National Category
Orthopedics Rheumatology and Autoimmunity
Research subject
Orthopaedics
Identifiers
URN: urn:nbn:se:umu:diva-103843DOI: 10.1016/j.joca.2014.07.023ISI: 000344186000003PubMedID: 25106677OAI: oai:DiVA.org:umu-103843DiVA: diva2:815951
Available from: 2015-06-02 Created: 2015-06-02 Last updated: 2017-12-04

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