umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland.
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.ORCID iD: 0000-0002-0982-6269
School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland.
Show others and affiliations
2014 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 40, no 9, 2162-2171 p.Article in journal (Refereed) Published
Abstract [en]

Ultrasound imaging has been proposed for diagnostics of osteoarthritis and cartilage injuries in vivo. However, the specific contribution of chondrocytes and collagen to ultrasound scattering in articular cartilage has not been systematically studied. We investigated the role of these tissue structures by measuring ultrasound scattering in agarose scaffolds with varying collagen and chondrocyte concentrations. Ultrasound catheters with center frequencies of 9 MHz (7.1–11.0 MHz, −6 dB) and 40 MHz (30.1–45.3 MHz, −6 dB) were applied using an intravascular ultrasound device. Ultrasound backscattering quantified in a region of interest starting right below sample surface differed significantly (p < 0.05) with the concentrations of collagen and chondrocytes. An ultrasound frequency of 40 MHz, as compared with 9 MHz, was more sensitive to variations in collagen and chondrocyte concentrations. The present findings may improve diagnostic interpretation of arthroscopic ultrasound imaging and provide information necessary for development of models describing ultrasound propagation within cartilage.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 40, no 9, 2162-2171 p.
Keyword [en]
ultrasound, imaging, articular cartilage, collagen, chondrocyte, scattering, attenuation
National Category
Physical Sciences Radiology, Nuclear Medicine and Medical Imaging
Research subject
Physics; cellforskning
Identifiers
URN: urn:nbn:se:umu:diva-103866DOI: 10.1016/j.ultrasmedbio.2014.03.016ISI: 000341461100028PubMedID: 24972499OAI: oai:DiVA.org:umu-103866DiVA: diva2:816017
Available from: 2015-06-02 Created: 2015-06-02 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Liukkonen, JukkaYlärinne, JanneLammi, Mikko
In the same journal
Ultrasound in Medicine and Biology
Physical SciencesRadiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 162 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf