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Determination of mechanical properties of chondrocytes in articular cartilage using atomic force microscopy
"Politehnica” University of Timisoara, Mechanical Engineering Faculty, Mechatronics Department, Timisoara, Romania; University of Eastern Finland, Department of Applied Physics, Kuopio, Finland.
Savonia University of Applied Sciences, School of Engineering and Technology, Kuopio, Finland.
University of Eastern Finland, Department of Biosciences, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)
“Politehnica” University of Timisoara, Mechanical Engineering Faculty, Mechatronics Department, Timisoara, Romania.
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2014 (English)In: Solid State Phenomena, ISSN 1012-0394, E-ISSN 1662-9779, Vol. 216, 134-139 p.Article in journal (Refereed) Published
Abstract [en]

Atomic Force Microscopy (AFM) based nanoindentation is a widely used technique for measuring mechanical properties of living cells, providing information for understanding their mechanobiological behavior. However, very local properties of cell surfaces have not been characterized earlier. The goal of this study was to develop an AFM-based technique to determine local elastic properties of bovine articular chondrocytes. The Youngs modulus of chondrocytes was 19.3 ± 5.6 kPa for spread cells and 10 ± 4.1 kPa for the round cells. The results were compared to previous studies in which different techniques were used to obtain more global properties of chondrocytes. Our findings suggest that using nanosized AFM tips, the very local cell properties can be measured.

Place, publisher, year, edition, pages
Trans Tech Publications Inc., 2014. Vol. 216, 134-139 p.
Keyword [en]
articular cartilage, atomic force microscopy, cell mechanics, chondrocyte, nanoindentation
National Category
Physical Sciences Cell and Molecular Biology
Research subject
biomechanics; cellforskning
Identifiers
URN: urn:nbn:se:umu:diva-103871DOI: 10.4028/www.scientific.net/SSP.216.134ISI: 000347924100023OAI: oai:DiVA.org:umu-103871DiVA: diva2:816074
Available from: 2015-06-02 Created: 2015-06-02 Last updated: 2017-12-04Bibliographically approved

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