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Preventing opioid overdose in Sweden: A cost-effectiveness analysis of naloxone distribution: A study protocol
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
2015 (English)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Literature Review: The gap in knowledge of opioid overdose prevention in Sweden has been identified and reviewed in order to plan a study protocol to evaluate the effectiveness and cost effectiveness of implementing a pilot naloxone distribution project in Malmö, Sweden. This literature review identifies the success of other studies in educating at-risk individuals in overdose prevention and strategies to reduce the rate of mortality and morbidity from interventions.

Objectives: To identify:

-             The gap in knowledge of effective overdose prevention in Sweden;

-             Useful cost and effect data for the investigation of whether naloxone distribution to potential witnesses of overdose is cost effective; and


Methods: Two interventions have been identified in this analysis; which include overdose prevention training, and overdose prevention training with naloxone distribution. Cost and effect data is identified for the application of a cost effectiveness analysis on this topic. DALYs have been chosen to measure the effectiveness of the interventions. Appropriate discounting rates and parameters for uncertainty have also been identified.

Populations: The included research population are the injecting drug users of the Skåne Region and Stockholm, Sweden.

Time Frame: The duration of the pilot project for naloxone distribution will determine the length of time that the interventions will be analysed. The pilot project has 3, 6, and 12 month follow-up periods.

Expected Outcomes: The implementation of a pilot project in naloxone distribution is expected to be the most cost-effective intervention in this analysis, due to the proven effectiveness of naloxone in reducing mortality and morbidity to those at risk of opioid overdose; and the relatively low cost of training participants in its administration, and other overdose prevention strategies. 

Place, publisher, year, edition, pages
2015. , 1989 p.
, Centre for Public Health Report Series, ISSN 1651-341X ; 2015:27
Keyword [en]
Harm Reduction, Naloxone, Sweden, Cost-Effectiveness, Study Protocol, Injection Drug Use, Overdose, Overdose Prevention
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-104340OAI: diva2:819153
Educational program
Master's Programme in Public Health (one-year)
2015-05-26, 10:45 (English)
Available from: 2016-04-07 Created: 2015-06-10 Last updated: 2016-04-07Bibliographically approved

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