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A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division
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2012 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 150, no 5, 1002-1015 p.Article in journal (Refereed) Published
Abstract [en]

In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOM-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a "flip flop" that constrains asymmetric cell division to the stem cell region.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 150, no 5, 1002-1015 p.
National Category
Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-104253DOI: 10.1016/j.cell.2012.07.017ISI: 000308500200014PubMedID: 22921914OAI: oai:DiVA.org:umu-104253DiVA: diva2:819242
Available from: 2015-06-10 Created: 2015-06-09 Last updated: 2017-12-04Bibliographically approved

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Cruz-Ramírez, AlfredoMiskolczi, PálMähönen, Ari PekkaXu, JianMurray, James A. H.Bako, Laszlo
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Department of Plant PhysiologyUmeå Plant Science Centre (UPSC)
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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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  • de-DE
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  • en-US
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Output format
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