Change search
ReferencesLink to record
Permanent link

Direct link
A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division
Show others and affiliations
2012 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 150, no 5, 1002-1015 p.Article in journal (Refereed) Published
Abstract [en]

In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOM-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a "flip flop" that constrains asymmetric cell division to the stem cell region.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 150, no 5, 1002-1015 p.
National Category
Biochemistry and Molecular Biology Cell Biology
URN: urn:nbn:se:umu:diva-104253DOI: 10.1016/j.cell.2012.07.017ISI: 000308500200014PubMedID: 22921914OAI: diva2:819242
Available from: 2015-06-10 Created: 2015-06-09 Last updated: 2015-11-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Cruz-Ramírez, AlfredoMiskolczi, PálMähönen, Ari PekkaXu, JianMurray, James A. H.Bako, Laszlo
By organisation
Department of Plant PhysiologyUmeå Plant Science Centre (UPSC)
In the same journal
Biochemistry and Molecular BiologyCell Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 54 hits
ReferencesLink to record
Permanent link

Direct link