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Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China
1Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China; Institute of Health Education of Xi’an, Xi’an, China.
Department of Orthopedics Surgery, Second Hospital, Xi’an Jiaotong University, Xi’an, China.
Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China.
Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China.
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2012 (English)In: Science China Life Sciences, ISSN 1674-7305, Vol. 55, no 12, 1057-1063 p., 23233220Article in journal (Refereed) Published
Abstract [en]

n this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2012. Vol. 55, no 12, 1057-1063 p., 23233220
Keyword [en]
Kashin-Beck disease, Mitochondrial dysfunction, Ingenuity pathway analysis, Microarray, Cartilage
National Category
Cell and Molecular Biology Orthopedics Medical Genetics
Research subject
Genetics; Orthopaedics
Identifiers
URN: urn:nbn:se:umu:diva-104405DOI: 10.1007/s11427-012-4418-4OAI: oai:DiVA.org:umu-104405DiVA: diva2:819471
Available from: 2015-06-10 Created: 2015-06-10 Last updated: 2015-06-10

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