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The immunoglobulin M-degrading enzyme of Streptococcus suis, Ide(Ssuis), is a highly protective antigen against serotype 2
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2015 (Engelska)Ingår i: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 33, nr 19, s. 2207-2212Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immunogenicity and protective efficacy of a recombinant vaccine including IdeSsuis. Vaccination with rIdeSsuis elicited antibodies efficiently neutralizing the IgM protease activity. Importantly, 18 piglets vaccinated with rIdeSsuis alone or in combination with bacterin priming were completely protected against mortality and severe morbidity after S. suis serotype 2 challenge. In contrast, 12 of the 17 piglets either treated with the placebo or primed with the bacterin only, succumbed to S. suis disease. Immunity against Idessuis was associated with increased killing of S. suis wt in porcine blood ex vivo leading to a tenfold difference in the bacterial survival factor in blood of placebo-treated and rIdeSsuis-vaccinated piglets. In conclusion, the results of this study indicate that rIdeSsuis is a highly protective antigen in pigs.

Ort, förlag, år, upplaga, sidor
2015. Vol. 33, nr 19, s. 2207-2212
Nyckelord [en]
IgM protease, Streptococcus suis, Pigs, Bactericidal assay, Neutralizing antibodies
Nationell ämneskategori
Medicinsk biovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-103720DOI: 10.1016/j.vaccine.2015.03.047ISI: 000353734900003PubMedID: 25825330OAI: oai:DiVA.org:umu-103720DiVA, id: diva2:819750
Tillgänglig från: 2015-06-11 Skapad: 2015-05-28 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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von Pawel-Rammingen, Ulrich

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Institutionen för molekylärbiologi (Medicinska fakulteten)Umeå Centre for Microbial Research (UCMR)
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