Real-world outcome analysis of continuously and intermittently treated patients with moderate to severe psoriasis after switching to a biologic agent
2015 (English)In: Dermatology, ISSN 1018-8665, E-ISSN 1421-9832, Vol. 230, no 4, 347-353 p.Article in journal (Refereed) Published
Background: Clinical studies of continuous versus intermittent biologic therapy for moderate to severe psoriasis demonstrate improved efficacy with continuous treatment. Objective: To analyse Swedish real-world data of continuously and intermittently treated biologic-naive patients after switching to a biologic agent. Methods: This is an observational study based on PsoReg, the Swedish registry for systemic psoriasis treatment. Outcome effects in biologic-naive patients who switched to a biologic agent (n = 351) were analysed in groups of continuous, intermittent and terminated treatment. Results: Intermittently treated patients (n = 50) reported higher Psoriasis Area and Severity Index and Dermatology Life Quality Index values after switching than patients with continuous (n = 260) or terminated treatment (n = 41). Study Limitations:The reason for intermittent treatment was not recorded. The intermittently treated patients may be a heterogeneous group and a limitation is that it cannot be determined whether less than continuous use was offered to handle negative aspects. Conclusion: Patients with continuous biologic treatment tend to achieve better outcomes compared to intermittently treated patients.
Place, publisher, year, edition, pages
S. Karger, 2015. Vol. 230, no 4, 347-353 p.
Biologic agents, Intermittent treatment, Continuous treatment, Psoriasis, Register
Dermatology and Venereal Diseases
IdentifiersURN: urn:nbn:se:umu:diva-104914DOI: 10.1159/000371881ISI: 000354004000011PubMedID: 25721571OAI: oai:DiVA.org:umu-104914DiVA: diva2:821730