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Edin expression in the fat body is required in the defense against parasitic wasps in Drosophila melanogaster
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Laboratory of Genetic Immunology, BioMediTech, University of Tampere, Tampere, Finland.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Laboratory of Genetic Immunology, BioMediTech, University of Tampere, Tampere, Finland.
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2015 (English)In: PLoS Pathogens, ISSN 1553-7366, E-ISSN 1553-7374, Vol. 11, no 5, e1004895Article in journal (Refereed) Published
Abstract [en]

The cellular immune response against parasitoid wasps in Drosophila involves the activation, mobilization, proliferation and differentiation of different blood cell types. Here, we have assessed the role of Edin (elevated during infection) in the immune response against the parasitoid wasp Leptopilina boulardi in Drosophila melanogaster larvae. The expression of edin was induced within hours after a wasp infection in larval fat bodies. Using tissue-specific RNAi, we show that Edin is an important determinant of the encapsulation response. Although edin expression in the fat body was required for the larvae to mount a normal encapsulation response, it was dispensable in hemocytes. Edin expression in the fat body was not required for lamellocyte differentiation, but it was needed for the increase in plasmatocyte numbers and for the release of sessile hemocytes into the hemolymph. We conclude that edin expression in the fat body affects the outcome of a wasp infection by regulating the increase of plasmatocyte numbers and the mobilization of sessile hemocytes in Drosophila larvae.

Place, publisher, year, edition, pages
Public library science , 2015. Vol. 11, no 5, e1004895
National Category
Infectious Medicine Microbiology in the medical area
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URN: urn:nbn:se:umu:diva-105266DOI: 10.1371/journal.ppat.1004895ISI: 000355269300039PubMedID: 25965263OAI: oai:DiVA.org:umu-105266DiVA: diva2:824590
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2017-12-04Bibliographically approved

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