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Preserved somatosensory conduction in a patient with complete cervical spinal cord injury
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Fysiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Rehabiliteringsmedicin.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Fysiologi. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Department of Neurobiology, Care Sciences and Society (Neurorehabilitation), Karolinska Institute, Stockholm, Sweden.
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2015 (Engelska)Ingår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 47, nr 5, s. 426-431Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Neurophysiological investigation has shown that patients with clinically complete spinal cord injury can have residual motor sparing ("motor discomplete"). In the current study somatosensory conduction was assessed in a patient with clinically complete spinal cord injury and a novel ethodology for assessing such preservation is described, in this case indicating "sensory discomplete" spinal cord injury. Methods: Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) was used to examine the somatosensory system in a healthy subject and in a subject with a clinically complete cervical spinal cord injury, by applying tactile stimulation above and below the level of spinal cord injury, with and without visual feedback. Results: In the participant with spinal cord injury, somatosensory stimulation below the neurological level of the lesion gave rise to BOLD signal changes in the corresponding areas of the somatosensory cortex. Visual feedback of the stimulation strongly modulated the somatosensory BOLD signal, implying that cortico-cortical rather than spino-cortical connections can drive activity in the somatosensory cortex. Critically, BOLD signal change was also evident when the visual feedback of the stimulation was removed, thus demonstrating sensory discomplete spinal cord injury. Conclusion: Given the existence of sensory discomplete spinal cord injury, preserved but hitherto undetected somatosensory conduction might contribute to the unexplained variability related to, for example, the propensity to develop decubitus ulcers and neuropathic pain among patients with clinically complete spinal cord injury.

Ort, förlag, år, upplaga, sidor
Foundation of Rehabilitation Information , 2015. Vol. 47, nr 5, s. 426-431
Nyckelord [en]
fMRI, spinal cord injury, complete, non-conscious, somatosensory cortex
Nationell ämneskategori
Idrottsvetenskap Sjukgymnastik
Identifikatorer
URN: urn:nbn:se:umu:diva-105263DOI: 10.2340/16501977-1955ISI: 000355371600006PubMedID: 25808357OAI: oai:DiVA.org:umu-105263DiVA, id: diva2:824613
Tillgänglig från: 2015-06-22 Skapad: 2015-06-22 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Awad, AmarLevi, RichardLindgren, LenitaWestling, GöranNyberg, LarsEriksson, Johan

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Awad, AmarLevi, RichardLindgren, LenitaWestling, GöranNyberg, LarsEriksson, Johan
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Umeå centrum för funktionell hjärnavbildning (UFBI)FysiologiRehabiliteringsmedicinInstitutionen för strålningsvetenskaper
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Journal of Rehabilitation Medicine
IdrottsvetenskapSjukgymnastik

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