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Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing rheumatoid arthritis: a cross-sectional study.
Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, Göteborgs universitet.
2011 (English)In: BMC musculoskeletal disorders, ISSN 1471-2474, Vol. 12, 242- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The aims were to explore bone mineral density (BMD) by digital X-ray radiogrammetry (DXR) in postmenopausal women with long-lasting rheumatoid arthritis (RA) in relation to dual x-ray absorptiometry (DXA)-BMD, joint destruction by conventional radiographs and disease related variables in a cross-sectional study.

METHODS: Seventy-five postmenopausal women with RA were examined by DXA measuring DXA-BMD of the forearm, total hip and lumbar spine, by scoring joint destruction on plain radiographs by the method of Larsen and by DXR-BMD in metacarpals two to four. The DXR-BMD results of the RA women were compared with an age and sex-matched reference database. A function of DXR-BMD in relation to age and disease duration was created. Associations were investigated by bivariate and multiple linear regression analyses.

RESULTS: DXR-BMD was strongly decreased in RA patients compared to the reference database (p < 0.001). Calculations showed that DXR-BMD was not markedly influenced the first years after diagnosis of RA, but between approximately 5-10 years of disease there was a steep decline in DXR-BMD which subsequently levelled off. In multiple regression analyses disease duration, CRP and DXR-BMD were independent variables associated with Larsen score (R2= 0.64). Larsen score and BMD forearm were independent determinants of DXR-BMD (R2 = 0.79).

CONCLUSIONS: DXR-BMD was strongly reduced and associated with both Larsen score and DXA-BMD forearm in these postmenopausal women with RA implying that DXR-BMD is a technique that reflects both the erosive process and bone loss adjacent to affected joints.

Place, publisher, year, edition, pages
2011. Vol. 12, 242- p.
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-105469DOI: 10.1186/1471-2474-12-242PubMedID: 22024200OAI: diva2:825634
Available from: 2015-06-24 Created: 2015-06-24 Last updated: 2015-06-24

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Forsblad-d'Elia, Helena
Rheumatology and Autoimmunity

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