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The WNT system: background and its role in bone
Umeå University, Faculty of Medicine, Department of Odontology. Centre for Bone and Arthritis Research, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Centre for Bone and Arthritis Research, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
2015 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 277, no 6, 630-649 p.Article in journal (Refereed) Published
Abstract [en]

WNTs are extracellular proteins that activate different cell surface receptors linked to canonical and noncanonical WNT signalling pathways. The Wnt genes were originally discovered as important for embryonic development of fruit flies and malignant transformation of mouse mammary cancers. More recently, WNTs have been implicated in a wide spectrum of biological phenomena and diseases. During the last decade, several lines of clinical and preclinical evidence have indicated that WNT signalling is critical for trabecular and cortical bone mass, and this pathway is currently an attractive target for drug development. Based on detailed knowledge of the different WNT signalling pathways, it appears that it might be possible to develop drugs that specifically target cortical and trabecular bone. Neutralization of a bone-specific WNT inhibitor is now being evaluated as a promising anabolic treatment for patients with osteoporosis. Here, we provide the historical background to the discoveries of WNTs, describe the different WNT signalling pathways and summarize the current understanding of how these proteins regulate bone mass by affecting bone formation and resorption.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 277, no 6, 630-649 p.
Keyword [en]
bone, osteoblast, osteoclast, sclerostin, WNT
National Category
Orthopedics
Identifiers
URN: urn:nbn:se:umu:diva-105247DOI: 10.1111/joim.12368ISI: 000355000400002PubMedID: 25845559OAI: oai:DiVA.org:umu-105247DiVA: diva2:825858
Available from: 2015-06-24 Created: 2015-06-22 Last updated: 2017-12-04Bibliographically approved

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Lerner, Ulf H

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CiteExportLink to record
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  • nn-NB
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