Effekter av farmakologisk behandling och träning på lipidprofilen i blodet
Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesis
Low physical activity levels and obesity are independent risk factors for the development of dyslipidemia, atherosclerosis, typ-2 diabetes and other cardiovascular diseases (CVD). At present, pharmaceutical cholesterol-lowering treatment with statins is the most common. Statins increases the risk of a variety of severe adverse effects, such as myalgia, rhabdomyolysis and hepatocellular injuries. Even though there is a substantial amount of sources that promote the application of training in cholesterol-lowering treatment, the usage of statins consistently increases in clinical practice. The purpose of this review was to analyse current research on training and pharmaceutical treatment and their effects on blood lipid levels. Delimitations were made regarding pharmaceutical treatment by selecting to focus primarily on simvastatin and atorvastatin, due to being the most frequently utilized blood lipid lowering drugs. Considering the training interventions we aimed to cover different types of training, including high and low intensity training, not physical activity in general. Both training and statin treatment shows cholesterol-lowering effects in total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), with greater alterations with statins. Meanwhile there are more consistent results of improving high-density lipoprotein cholesterol (HDL-C) levels within the training interventions. However, the clinical trials were not always comparable since included participants in the pharmaceutical trials often displayed dyslipidemic and CVD traits meanwhile training interventions mainly focused on untrained overweight, but otherwise classified as healthy subjects. In conclusion, there lies great potential in further investigating training, alone or in combination with pharmaceutical interventions, as a treatment method in dealing with dyslipidemia and other related risk factors. This potential being comprised of socioeconomical benefits, reducing possible adverse effects induced by statins, and also the life enhancing synergy effects of training.
Place, publisher, year, edition, pages
2015. , 28 p.
dyslipidemia, cholesterol-lowering, training, statins, exercise
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-106057OAI: oai:DiVA.org:umu-106057DiVA: diva2:839786
Physical Trainer Pogramme
Svensson, Michael, Med. Dr.
Gilenstam, Kajsa, Med. Dr.