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The role of exosomes in peripheral nerve regeneration
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2015 (English)In: Neural Regeneration Research, ISSN 1673-5374, E-ISSN 1876-7958, Vol. 10, no 5, 743-747 p.Article, review/survey (Refereed) Published
Abstract [en]

Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address these difficulties include autologous nerve grafts (which are currently the gold standard treatment) and synthetic conduits, with the latter option being able to be impregnated with Schwann cells or stem cells which provide an appropriate micro-environment for neuronal regeneration to occur. Transplanting stem cells, however, infers additional risk of malignant transformation as well as manufacturing difficulties and ethical concerns, and the use of autologous nerve grafts and Schwann cells requires the sacrifice of a functioning nerve. A new approach utilizing exosomes, secreted extracellular vesicles, could avoid these complications. In this review, we summarize the current literature on exosomes, and suggest how they could help to improve axonal regeneration following peripheral nerve injury.

Place, publisher, year, edition, pages
2015. Vol. 10, no 5, 743-747 p.
Keyword [en]
axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite tgrowth, peripheral nerve injury, Schwann cell, stem cell
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-106030DOI: 10.4103/1673-5374.156968ISI: 000355964400019OAI: oai:DiVA.org:umu-106030DiVA: diva2:839928
Available from: 2015-07-06 Created: 2015-07-03 Last updated: 2017-12-04Bibliographically approved

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Ching, Rosanna C.Kingham, Paul J.
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Department of Integrative Medical Biology (IMB)Department of Surgical and Perioperative Sciences
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Neural Regeneration Research
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Neurosciences

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