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Host Actin Polymerization Tunes the Cell Division Cycle of an Intracellular Pathogen
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
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2015 (English)In: Cell reports, ISSN 2211-1247, Vol. 11, no 4, 499-507 p.Article in journal (Refereed) Published
Abstract [en]

Growth and division are two of the most fundamental capabilities of a bacterial cell. While they are well described for model organisms growing in broth culture, very little is known about the cell division cycle of bacteria replicating in more complex environments. Using a D-alanine reporter strategy, we found that intracellular Listeria monocytogenes (Lm) spend a smaller proportion of their cell cycle dividing compared to Lm growing in broth culture. This alteration to the cell division cycle is independent of bacterial doubling time. Instead, polymerization of host-derived actin at the bacterial cell surface extends the non-dividing elongation period and compresses the division period. By decreasing the relative proportion of dividing Lm, actin polymerization biases the population toward cells with the highest propensity to form actin tails. Thus, there is a positive-feedback loop between the Lm cell division cycle and a physical interaction with the host cytoskeleton.

Place, publisher, year, edition, pages
2015. Vol. 11, no 4, 499-507 p.
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Cell Biology
URN: urn:nbn:se:umu:diva-106286DOI: 10.1016/j.celrep.2015.03.046ISI: 000353902600001PubMedID: 25892235OAI: diva2:840999
Available from: 2015-07-10 Created: 2015-07-09 Last updated: 2015-07-10Bibliographically approved

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Espaillat, AkbarCava, Felipe
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