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Peripheral nerve regeneration: experimental strategies and future perspectives
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
2015 (English)In: Advanced Drug Delivery Reviews, ISSN 0169-409X, E-ISSN 1872-8294, Vol. 82-83, 160-167 p.Article, review/survey (Refereed) Published
Abstract [en]

Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options. This review summarises all the events occurring after nerve damage at the level of the cell body, the site of injury and the target organ. Various experimental strategies to improve neuronal survival, axonal regeneration and target reinnervation are described including pharmacological approaches and cell-based therapies. Given the complexity of nerve regeneration, further studies are needed to address the biology of nerve injury, to improve the interaction with implantable scaffolds, and to implement cell-based therapies in nerve tissue engineering. 

Place, publisher, year, edition, pages
2015. Vol. 82-83, 160-167 p.
Keyword [en]
Peripheral nerve regeneration, Neuronal survival, Reinnervation, Muscle denervation, Scaffold, Stem cell
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:umu:diva-106377DOI: 10.1016/j.addr.2014.11.010ISI: 000353737200019PubMedID: 25446133OAI: diva2:841823
Available from: 2015-07-15 Created: 2015-07-14 Last updated: 2015-07-15Bibliographically approved

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