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Commissural axonal corridors instruct neuronal migration in the mouse spinal cord
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
2015 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, 7028Article in journal (Refereed) Published
Abstract [en]

Unravelling how neurons are guided during vertebrate embryonic development has wide implications for understanding the assembly of the nervous system. During embryogenesis, migration of neuronal cell bodies and axons occurs simultaneously, but to what degree they influence each other's development remains obscure. We show here that within the mouse embryonic spinal cord, commissural axons bisect, delimit or preconfigure ventral interneuron cell body position. Furthermore, genetic disruption of commissural axons results in abnormal ventral interneuron cell body positioning. These data suggest that commissural axonal fascicles instruct cell body position by acting either as border landmarks (axon-restricted migration), which to our knowledge has not been previously addressed, or acting as cellular guides. This study in the developing spinal cord highlights an important function for the interaction of cell bodies and axons, and provides a conceptual proof of principle that is likely to have overarching implications for the development of neuronal architecture.

Place, publisher, year, edition, pages
2015. Vol. 6, 7028
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-106511DOI: 10.1038/ncomms8028ISI: 000355530100002PubMedID: 25960414OAI: oai:DiVA.org:umu-106511DiVA: diva2:841941
Available from: 2015-07-15 Created: 2015-07-14 Last updated: 2017-12-04Bibliographically approved

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Laumonnerie, ChristopheTong, Yong GuangAlstermark, HelenaWilson, Sara I.
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