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Reversal of Heparin After Cardiac Surgery: Protamine Titration Using a Statistical Model
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
2015 (English)In: Journal of Cardiothoracic and Vascular Anesthesia, ISSN 1053-0770, E-ISSN 1532-8422, Vol. 29, no 3, 710-714 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To establish a statistical model for determination of protamine dose in conjunction with cardiopulmonary bypass. Design: Prospective.

Setting: University hospital.

Participants: Ninety consecutive cardiac surgical patients.

Interventions: None.

Measurements and Main Results: A series of clinically oriented variables were introduced into a statistical model for projection of the protamine dose after cardiopulmonary bypass. The following significant predictors were identified using multivariable regression analysis: The patient's body surface area, the administered dose of heparin, heparin clearance, and the preoperative platelet count. The statistical model projected the protamine dose within 3 +/- 23 mg of the point-of-care test used as reference.

Conclusion: Protamine dosing based on statistical modeling represents an alternative to point-of-care tests.

Place, publisher, year, edition, pages
2015. Vol. 29, no 3, 710-714 p.
Keyword [en]
cardiac surgery, cardiopulmonary bypass, protamine, heparin, point-of-care testing, statistical modeling
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-106499DOI: 10.1053/j.jvca.2014.12.006ISI: 000355643500025OAI: oai:DiVA.org:umu-106499DiVA: diva2:842064
Available from: 2015-07-16 Created: 2015-07-14 Last updated: 2017-12-04Bibliographically approved

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Ödling Davidsson, FredrikJohagen, DanielAppelblad, MicaelSvenmarker, Staffan
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SurgeryDepartment of Surgical and Perioperative Sciences
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Journal of Cardiothoracic and Vascular Anesthesia
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CiteExportLink to record
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