Reversal of Heparin After Cardiac Surgery: Protamine Titration Using a Statistical Model
2015 (English)In: Journal of Cardiothoracic and Vascular Anesthesia, ISSN 1053-0770, E-ISSN 1532-8422, Vol. 29, no 3, 710-714 p.Article in journal (Refereed) Published
Objective: To establish a statistical model for determination of protamine dose in conjunction with cardiopulmonary bypass. Design: Prospective.
Setting: University hospital.
Participants: Ninety consecutive cardiac surgical patients.
Measurements and Main Results: A series of clinically oriented variables were introduced into a statistical model for projection of the protamine dose after cardiopulmonary bypass. The following significant predictors were identified using multivariable regression analysis: The patient's body surface area, the administered dose of heparin, heparin clearance, and the preoperative platelet count. The statistical model projected the protamine dose within 3 +/- 23 mg of the point-of-care test used as reference.
Conclusion: Protamine dosing based on statistical modeling represents an alternative to point-of-care tests.
Place, publisher, year, edition, pages
2015. Vol. 29, no 3, 710-714 p.
cardiac surgery, cardiopulmonary bypass, protamine, heparin, point-of-care testing, statistical modeling
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:umu:diva-106499DOI: 10.1053/j.jvca.2014.12.006ISI: 000355643500025OAI: oai:DiVA.org:umu-106499DiVA: diva2:842064