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Acoustic properties of trabecular bone–relationships to tissue composition.
Department of Physics, University of Kuopio, Kuopio, Finland.
Department of Physics, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)ORCID iD: 0000-0002-6181-9904
Department of Physics, University of Kuopio, Kuopio, Finland; Department of Physics, University of Kuopio, Kuopio, Finland.
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2007 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 33, no 9, 1438-1444 p., 17561333Article in journal (Refereed) Published
Abstract [en]

In osteoporosis, changes in tissue composition and structure reduce bone strength and expose it to fractures. The current primary diagnostic technique, i.e., dual energy X-ray absorptiometry, measures areal bone mineral density (BMD) but provides no direct information on trabecular structure or organic composition. Although still poorly characterized, ultrasound techniques may bring about information on bone composition and structure. In this study, relationships of 2.25-MHz ultrasound speed, attenuation, reflection and backscattering with composition of human trabecular bone (n=26) were characterized experimentally, as well as by using numerical analyses. We also determined composition of the trabecular sample (fat and water content, bone volume fraction) and that of the calcified matrix (mineral, proteoglycan and collagen content of trabeculae). In experimental analyses, bone volume fraction and mineral content of the calcified matrix were the only determinants of BMD. Further, bone volume fraction served as the strongest determinant of ultrasound parameters (r=0.51-0.87). In numerical simulations, density and mechanical properties of the calcified matrix systematically affected ultrasound speed, attenuation, reflection and backscattering. However, partial correlation coefficients revealed only low associations(|r|<or=0.4) between the composition of calcified matrix and ultrasound parameters in experimental measurements. To conclude, the content and structure of calcified matrix, rather than its composition, affect more significantly acoustic properties of healthy trabecular bone.

Place, publisher, year, edition, pages
Elsevier, 2007. Vol. 33, no 9, 1438-1444 p., 17561333
Keyword [en]
Bone, ultrasound, osteoporosis, trabecular bone, DXA, composition
National Category
Medical Engineering Orthopedics Medical Laboratory and Measurements Technologies
Research subject
Orthopaedics; Physiological Botany
Identifiers
URN: urn:nbn:se:umu:diva-106632DOI: 10.1016/j.ultrasmedbio.2007.04.004PubMedID: 17561333OAI: oai:DiVA.org:umu-106632DiVA: diva2:843083
Available from: 2015-07-25 Created: 2015-07-25 Last updated: 2017-12-04

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