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Effect of human trabecular bone composition on its electrical properties.
Department of Physics, University of Kuopio, Kuopio, Finland.
Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)ORCID iD: 0000-0002-6181-9904
Department of Physics, University of Kuopio, Kuopio, Finland.
Department of Physics, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
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2007 (English)In: Medical Engineering and Physics, ISSN 1350-4533, E-ISSN 1873-4030, Vol. 29, no 8, 845-852 p., 17097909Article in journal (Refereed) Published
Abstract [en]

Mechanical properties of bone are determined not only by bone mineral density (BMD), but also by tissue trabecular structure and organic composition. Impedance spectroscopy has shown potential to diagnose trabecular bone BMD and strength, however, the relationships between organic composition and electrical and dielectric properties have not been systematically investigated. To investigate these issues organic composition of 26 human trabecular bone samples harvested from the distal femur and proximal tibia was determined and compared with relative permittivity, loss factor, conductivity, phase angle, specific impedance and dissipation factor measured at wide range (50 Hz to 5 MHz) of frequencies. A strong linear correlation was found between the relative permittivity at 1.2 MHz and trabecular bone fat content (r = -0.85, p<0.01, n=26). On the other hand, relative permittivity measured at 200 Hz served as a good predictor of water content (r = 0.83). Phase angle, specific impedance and especially conductivity were strongly related to the trabecular bone dry density and water content (|r| > or = 0.69). Variation in bone tissue collagen content was strongly related to the relative permittivity measured at 1.2 MHz (r = 0.64), but only moderately to other parameters. Glycosaminoglycan content showed no significant relations with any investigated electrical parameters. The present study indicates that if the trabecular bone composition is known, the relationships presented in this study could facilitate calculation of current field distribution, e.g. during electrical stimulation of osteogenesis. On the other hand, our results suggest that permittivity measured at low (<1 kHz) or high (>100 kHz) frequencies could be used, e.g. during implant surgery, for prediction of trabecular bone water or fat contents, respectively.

Place, publisher, year, edition, pages
Elsevier, 2007. Vol. 29, no 8, 845-852 p., 17097909
Keyword [en]
Bone, impedance spectroscopy, electrical prperties, organic composition, permittivity, collagen
National Category
Orthopedics Biomedical Laboratory Science/Technology Other Physics Topics
Research subject
Biochemistry; Orthopaedics
URN: urn:nbn:se:umu:diva-106636DOI: 10.1016/j.medengphy.2006.09.007PubMedID: 17097909OAI: diva2:843099
Available from: 2015-07-26 Created: 2015-07-26 Last updated: 2015-07-26

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Lammi, Mikko
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