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Hydrostatic pressure-induced changes in cellular protein synthesis.
Department of Anatomy, University of Kuopio, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)ORCID iD: 0000-0002-6181-9904
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
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2004 (English)In: Biorheology, ISSN 0006-355X, E-ISSN 1878-5034, Vol. 41, no 3-4, 309-313 p., 15299263Article, review/survey (Refereed) Published
Abstract [en]

Hydrostatic pressure is a well-known effector of cellular protein synthesis. High continuous hydrostatic pressure inhibits protein synthesis in general. It has been known for a long time that 30S ribosomal subunit is associated with the effects of pressure on protein synthesis in prokaryotes, however, the mechanisms of action are still not completely understood. Our new data suggest that synthesis of eukaryotic elongation factor-2 (eEF-2) is decreased under 30 MPa continuous hydrostatic pressure. Thus, eEF-2 may have a role in the synthesis of pressure-regulated proteins in eukaryotic cells. The presence of pressure-sensitive proteins indicate that hydrostatic pressure can induce very specific responses in stressed cells. Accumulation of heat shock protein 70 and 90 beta occurs under high pressure, independent of the general inhibition of protein synthesis, although this response appears clearly weaker than during heat stress.

Place, publisher, year, edition, pages
IOS Press, 2004. Vol. 41, no 3-4, 309-313 p., 15299263
Keyword [en]
Hydrostatic pressure, protein synthesis, stress response, heat shock protein
National Category
Cell and Molecular Biology Biochemistry and Molecular Biology
Research subject
Biochemistry; cellforskning
Identifiers
URN: urn:nbn:se:umu:diva-106849PubMedID: 15299263OAI: oai:DiVA.org:umu-106849DiVA: diva2:845165
Available from: 2015-08-11 Created: 2015-08-11 Last updated: 2017-12-04

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Lammi, Mikko

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