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Speed of sound in normal and degenerated bovine articular cartilage.
Department of Applied Physics, University of Kuopio, Kuopio, Finland.
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland. (Chondrogenic and Osteogenic Differentiation Group)ORCID iD: 0000-0002-6181-9904
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2003 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, Vol. 29, no 3, 447-454 p., 12706196Article in journal (Refereed) Published
Abstract [en]

The unknown and variable speed of sound may impair accuracy of the acoustic measurement of cartilage properties. In this study, relationships between the speed of sound and cartilage composition, mechanical properties and degenerative state were studied in bovine knee and ankle cartilage (n = 62). Further, the effect of speed variation on the determination of cartilage thickness and stiffness with ultrasound (US) indentation was numerically simulated. The speed of sound was significantly (n = 32, p < 0.05) dependent on the cartilage water content (r = -0.800), uronic acid content (per wet weight, r = 0.886) and hydroxyproline content (per wet weight, r = 0.887, n = 28), Young's modulus at equilibrium (r = 0.740), dynamic modulus (r = 0.905), and degenerative state (i.e., Mankin score) (r = -0.727). In addition to cartilage composition, mechanical and acoustic properties varied significantly between different anatomical locations. In US indentation, cartilage is indented with a US transducer. Deformation and thickness of tissue are calculated using a predefined speed of sound and used in determination of dynamic modulus. Based on the simulations, use of the mean speed of sound of 1627 m/s (whole material) induced a maximum error of 7.8% on cartilage thickness and of 6.2% on cartilage dynamic modulus, as determined with the US indentation technique (indenter diameter 3 mm). We believe that these errors are acceptable in clinical US indentation measurements.

Place, publisher, year, edition, pages
Elsevier, 2003. Vol. 29, no 3, 447-454 p., 12706196
Keyword [en]
Articular cartilage, Osteoarthritis, indentation, Young's modulus, thickness, proteoglycans, collagen
National Category
Cell and Molecular Biology Biochemistry and Molecular Biology Radiology, Nuclear Medicine and Medical Imaging Orthopedics
Research subject
Biochemistry; biomechanics; Orthopaedics; Radiology
URN: urn:nbn:se:umu:diva-107042DOI: 10.1016/S0301-5629(02)00708-1PubMedID: 12706196OAI: diva2:846644
Available from: 2015-08-17 Created: 2015-08-17 Last updated: 2015-08-17

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