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Neuronal cells show regulatory differences in the hsp70 gene response.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Surgery, Kuopio University Hospital, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland.
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2002 (English)In: Brain Research. Molecular Brain Research, ISSN 0169-328X, E-ISSN 1872-6941, Vol. 101, no 1-2, 136-140 p., 12007842Article in journal (Refereed) Published
Abstract [en]

The synthesis of heat shock proteins (Hsps), encoded by heat shock genes, is increased in response to various stress stimuli. Hsps function as molecular chaperones, they dissociate cytotoxic stress-induced protein aggregates within cells and ensure improved survival. Induction of heat shock genes is mainly regulated at the transcriptional level. The stress responsive transcription factor, heat shock factor 1 (HSF1), is involved in the transcriptional induction of the heat shock genes. Our objective was to examine how hsp70 genes are regulated in different transformed and primary neurons upon exposure to elevated temperature. Our findings reveal that the Hsp70 response is regulated at the translational level in Neuro-2a neuroblastoma cells, while the IMR-32 neuroblastoma cells respond to stress by the classical HSF1-driven transcriptional regulatory mechanism. Primary rat hippocampal neurons show a lack of HSF1 and induction of the hsp70 gene. These observations suggest that neuronal cells display different hsp70 gene expression patterns which range from undetected response to transcriptional and posttranscriptional regulation during heat stress.

Place, publisher, year, edition, pages
Elsevier, 2002. Vol. 101, no 1-2, 136-140 p., 12007842
Keyword [en]
Neuronal cells, stress response, hydrostatic pressure, heat shock protein 70
National Category
Cell and Molecular Biology Biochemistry and Molecular Biology Neurosciences
Research subject
Biochemistry; cellforskning; Molecular Biology; Neurology
URN: urn:nbn:se:umu:diva-107124DOI: 10.1016/S0169-328X(02)00179-1PubMedID: 12007842OAI: diva2:847078
Available from: 2015-08-19 Created: 2015-08-19 Last updated: 2015-08-19

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Lammi, Mikko
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