Extracellular matrix composition of full-thickness defect repair tissue is little influenced by exercise in rat articular cartilage.
2001 (English)In: Connective Tissue Research, ISSN 0300-8207, E-ISSN 1607-8438, Vol. 42, no 2, 97-109 p., 11718471Article in journal (Refereed) Published
Full-thickness articular cartilage defects in the femoral condyles of adult rats were examined four and eight weeks after injury. Quantitative polarized light microscopic analysis showed that birefringence of the tissue in the central repair area increased more in rats exercised on a treadmill. Glycosaminoglycan content in the repair tissue was also higher than in the intermittent active motion group at four weeks after injury, but by eight weeks the levels were similar in both groups. No normal-looking articular cartilage was formed in the lesions, and only in one animal type II collagen was observed in the superficial zone of repair tissue. No 3B3(-) antigenicity of the proteoglycans was seen during repair. In conclusion, exercise minimally modified the repair of full-thickness articular cartilage defects in adult rats. The repair in the exercised group may occur slightly faster in the early stages but no difference was seen at the eight week time interval between the exercised and the intermittently active group.
Place, publisher, year, edition, pages
2001. Vol. 42, no 2, 97-109 p., 11718471
Articular cartilage, cartilage repair, proteoglycans, exercise
Cell and Molecular Biology Biochemistry and Molecular Biology Sport and Fitness Sciences
Research subject Biochemistry; cellforskning
IdentifiersURN: urn:nbn:se:umu:diva-107133PubMedID: 11718471OAI: oai:DiVA.org:umu-107133DiVA: diva2:847128