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Gender related predictors of limited exercise capacity in heart failure
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. Clinic of Cardiology and Angiology, University Clinical Centre of Kosova, Prishtina, Republic of Kosovo.
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2013 (English)In: IJC Heart & Vessels, ISSN 2214-7632, Vol. 1, 11-16 p.Article in journal (Other academic) Published
Abstract [en]

Aim The aim of this study was to investigate the impact of gender on the prediction of limited exercise capacity in heart failure (HF) patients assessed by 6 minute walk test (6-MWT).

Methods In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and a Doppler echocardiographic study were performed in the same day. Conventional cardiac measurements were obtained and global LV dyssynchrony was indirectly assessed using total isovolumic time − t-IVT [in s/min; calculated as: 60 − (total ejection time − total filling time)] and Tei index (t-IVT/ejection time). Patients were divided into two groups according to gender, which were again divided into two subgroups based on the 6-MWT distance (Group I: ≤ 300 m, and Group II: > 300 m).

Results Female patients were younger (p = 0.02), and had higher left ventricular (LV) ejection fraction — EF (p = 0.007) but with similar 6-MWT distance to male patients (p = 68). Group I male patients had lower hemoglobin level (p = 0.02) and lower EF (p = 0.03), compared with Group II, but none of the clinical or echocardiographic variables differed between groups in female patients. In multivariate analysis, only t-IVT [0.699 (0.552–0.886), p = 0.003], and LV EF [0.908 (0.835–0.987), p = 0.02] in males, and NYHA functional class [4.439 (2.213–16.24), p = 0.02] in females independently predicted poor 6-MWT distance (< 300 m).

Conclusion Despite similar limited exercise capacity, gender determines the pattern of underlying cardiac disturbances; ventricular dysfunction in males and subjective NYHA class in female heart failure patients.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 1, 11-16 p.
Keyword [en]
Six-minute walk test, Doppler echocardiography, LV function and dyssynchrony, Gender
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-107143DOI: 10.1016/j.ijchv.2013.09.001ISI: 000332489100676OAI: diva2:847186
Available from: 2015-08-19 Created: 2015-08-19 Last updated: 2016-01-25Bibliographically approved

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Bajraktari, GaniIbrahimi, PranveraJashari, FisnikHenein, Michael Y
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