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Fibre typing of intrafusal fibres
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Odontology, Clinical Oral Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
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2015 (English)In: Journal of Anatomy, ISSN 0021-8782, E-ISSN 1469-7580, Vol. 227, no 2, 136-156 p.Article, review/survey (Refereed) Published
Abstract [en]

The first descriptions of muscle spindles with intrafusal fibres containing striated myofibrils and nervous elements were given approximately 150years ago. It took, however, another 100years to establish the presence of two types of intrafusal muscle fibres: nuclear bag and nuclear chain fibres. The present paper highlights primarily the contribution of Robert Banks in fibre typing of intrafusal fibres: the confirmation of the principle of two types of nuclear bag fibres in mammalian spindles and the variation in occurrence of a dense M-band along the fibres. Furthermore, this paper summarizes how studies from the Umea University group (Laboratory of Muscle Biology in the Department of Integrative Medical Biology) on fibre typing and the structure and composition of M-bands have contributed to the current understanding of muscle spindle complexity in adult humans as well as to muscle spindle development and effects of ageing. The variable molecular composition of the intrafusal sarcomeres with respect to myosin heavy chains and M-band proteins gives new perspectives on the role of the intrafusal myofibrils as stretch-activated sensors influencing tension/stiffness and signalling to nuclei.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015. Vol. 227, no 2, 136-156 p.
Keyword [en]
cytoskeleton, M-band, M-protein, muscle spindle, myomesin, nuclear bag, nuclear chain, titin
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URN: urn:nbn:se:umu:diva-106768DOI: 10.1111/joa.12338ISI: 000357951900004PubMedID: 26179023OAI: oai:DiVA.org:umu-106768DiVA: diva2:847528
Available from: 2015-08-20 Created: 2015-08-07 Last updated: 2017-12-04Bibliographically approved

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Thornell, Lars-EricCarlsson, LenaEriksson, Per-OlofLiu, Jing-XiaStål, PerPedrosa-Domellöf, Fatima

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Thornell, Lars-EricCarlsson, LenaEriksson, Per-OlofLiu, Jing-XiaStål, PerPedrosa-Domellöf, Fatima
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