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Ectopic calcification and bone: a comparison of the effect of dietary carbohydrates, sugars and protein
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. (Heart Centre)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. (Heart Centre)
2014 (English)In: International Cardiovascular Forum Journal, ISSN 2410-2636, Vol. 1, no 4, 175-179 p.Article in journal (Refereed) Published
Abstract [en]

A number of studies have shown that severe calcification of the arteries, heart and kidneys commonly coexists withosteoporosis, particularly in renal disease. We have already shown that with respect to dietary fats, those that promoteectopic (mainly cardiovascular) calcification are also detrimental to bone, with a similar relationship seen in fats which inhibitectopic calcification. This review of dietary carbohydrates, sugars and protein has shown a similar correspondence of effect,with protein proving protective against ectopic calcification, at least in animals, and beneficial to bone. There appears to bean interaction with calcium intake, with the beneficial effects of high protein being negated in a calcium deficiency, while ahigh calcium intake enhances the dangers of a low protein intake; the cut-off for calcium intake may be around 800mg/dfor bone health. The results of studies on carbohydrates are unclear. Although there are no human studies on ectopiccalcification and intake of sugars, diabetes mellitus, insulin resistance and high blood glucose are known risk factors and arealso detrimental to bone. Fructose consistently promotes ectopic calcification in animals and is detrimental to bone in bothanimals and humans, although the results for sucrose, glucose and lactose are mixed. Protein and prebiotics, both protectiveagainst ectopic calcification and beneficial to bone, appear to act by increasing calcium absorption. Mechanisms of actionshared between inhibition of ectopic calcification and increased bone mineral density (BMD) include insulin-like growth factor(IGF)-1, which can be directly induced by protein and glucose, and advanced glycation end products (AGEs), which decreaseexpression of IGF-1 and generate reactive oxygen species, promote ectopic calcification and increased bone resorption.

Place, publisher, year, edition, pages
Barcaray International Publishing , 2014. Vol. 1, no 4, 175-179 p.
National Category
Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:umu:diva-107221DOI: 10.17987/icfj.v1i4.46OAI: oai:DiVA.org:umu-107221DiVA: diva2:847531
Available from: 2015-08-20 Created: 2015-08-20 Last updated: 2015-10-26Bibliographically approved

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Nicoll, RachelHenein, Michael Y

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