Increase of decorin content in articular cartilage following running.
1998 (English)In: Connective Tissue Research, ISSN 0300-8207, E-ISSN 1607-8438, Vol. 37, no 3-4, 295-302 p., 9862228Article in journal (Refereed) Published
The effect of long distance running exercise (40 km/day for 15 weeks, five days a week) on the decorin content of articular cartilage from the knee joint was studied in female beagle dogs. Samples from load bearing sites on the lateral plateau of the tibia (TL), and pooled material from two minimum load bearing sites on the posterior section of lateral (FLP) and medial (FMP) femoral condyles were analyzed. The running exercise protocol did not lead to significant changes in the overall glycosaminoglycan content of the cartilage. However, the amount of decorin significantly increased in the TL samples, and also in the FMP pool. These results support earlier in vitro observations that decorin synthesis is stimulated by loading, independent of the synthesis of aggrecan.
Place, publisher, year, edition, pages
Informa Healthcare, 1998. Vol. 37, no 3-4, 295-302 p., 9862228
Articualr cartilage, dog, proteogylcans, decorin, exercise
Cell and Molecular Biology Biochemistry and Molecular Biology
Research subject Biochemistry; cellforskning
IdentifiersURN: urn:nbn:se:umu:diva-107664PubMedID: 9862228OAI: oai:DiVA.org:umu-107664DiVA: diva2:848734