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Enhancement of AA-amyloid formation in mice by transthyretin amyloid fragments and polyethylene glycol.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2000 (English)In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1474, no 3, 331-6 p.Article in journal (Refereed) Published
Abstract [en]

The mechanism behind amyloid formation is unknown in all types of amyloidosis. Several substances can enhance amyloid formation in animal experiments. To induce secondary systemic amyloid (AA-type amyloid) formation, we injected silver nitrate into mice together with either amyloid fibrils obtained from patients with familial polyneuropathy (FAP) type I or polyethylene glycol (PEG). Mice injected with silver nitrate only served as controls. Amyloid deposits were detectable at day 3 in animals injected with amyloid fibrils and in those injected with PEG, whereas in control mice, deposits were not noted before day 12. Our results indicate that amyloid fibrils from FAP patients and even a non-sulfate containing polysaccharide (PEG) have the potential to act as amyloid-enhancing factors.

Place, publisher, year, edition, pages
2000. Vol. 1474, no 3, 331-6 p.
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Gastroenterology and Hepatology
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URN: urn:nbn:se:umu:diva-107788PubMedID: 10779684OAI: oai:DiVA.org:umu-107788DiVA: diva2:849509
Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2017-12-04

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