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Morbidity and mortality after surgery for cancer of the oesophagus and astro-oesophageal junction: a randomized clinical trial of neoadjuvant hemotherapy vs. neoadjuvant chemoradiation
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2015 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 41, no 7, p. 920-926Article in journal (Refereed) Published
Abstract [en]

Objective: To compare the incidence and severity of postoperative omplications after oesophagectomy for carcinoma of the oesophagus and astro-oesophageal junction (GOJ) after randomized accrual to eoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT). ackground: Neoadjuvant therapy improves long-term survival after esophagectomy. To date, evidence is insufficient to determine whether ombined nCT, or nCRT alone, is the most beneficial. ethods: Patients with carcinoma of the oesophagus or GOJ, resectable ith a curative intention, were enrolled in this multicenter trial onducted at seven centres in Sweden and Norway. Study participants re andomized to nCT or nCRT followed by surgery with two-field ymphadenectomy. Three cycles of cisplatin/5-fluorouracil was dministered in all patients, while 40 Gy of concomitant radiotherapy as administered in the nCRT group. esults: Of the randomized 181 patients, 91 were assigned to nCT and 90 o nCRT. One-hundred-and-fifty-five patients, 78 nCT and 77 nCRT, nderwent resection. There was no statistically significant difference etween the groups in the incidence of surgical or nonsurgical omplications (P-value = 0.69 and 0.13, respectively). There was no 0-day mortality, while the 90-day mortality was 3% (2/78) in the nCT roup and 6% (5/77) in the nCRT group (P = 0.24). The median lavien-Dindo complication severity grade was significantly higher in he nCRT. group (P = 0.001). onclusion: There was no significant difference in the incidence of omplications between patients randomized to nCT and nCRT. However, omplications were significantly more severe after nCRT. Registration rial database: The trial was registered in the Clinical Trials tabase registration number NCT01362127). 

Place, publisher, year, edition, pages
2015. Vol. 41, no 7, p. 920-926
Keywords [en]
Oesophageal cancer, Neoadjuvant treatment, Oesophagectomy complications
National Category
Surgery Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-107083DOI: 10.1016/j.ejso.2015.03.226ISI: 000357228000017PubMedID: 25908010OAI: oai:DiVA.org:umu-107083DiVA, id: diva2:849960
Available from: 2015-08-31 Created: 2015-08-18 Last updated: 2018-03-15Bibliographically approved

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