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Skilled forelimb movements and internal copy motor circuits
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
2015 (English)In: Current Opinion in Neurobiology, ISSN 0959-4388, E-ISSN 1873-6882, Vol. 33, 16-24 p.Article in journal (Refereed) Published
Abstract [en]

Mammalian skilled forelimb movements are remarkable in their precision, a feature that emerges from the continuous adjustment of motor output. Here we discuss recent progress in bridging the gap between theory and neural implementation in understanding the basis of forelimb motor refinement. One influential theory is that feedback from internal copy motor pathways enables fast prediction, through a forward model of the limb, an idea supported by behavioral studies that have explored how forelimb movements are corrected online and can adapt to changing conditions. In parallel, neural substrates of forelimb internal copy pathways are coming into clearer focus, in part through the use of genetically tractable animal models to isolate spinal and cerebellar circuits and explore their contributions to movement.

Place, publisher, year, edition, pages
2015. Vol. 33, 16-24 p.
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URN: urn:nbn:se:umu:diva-108471DOI: 10.1016/j.conb.2014.12.009ISI: 000359960800004PubMedID: 25588912OAI: diva2:855633
Available from: 2015-09-22 Created: 2015-09-11 Last updated: 2015-09-22Bibliographically approved

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