Change search
ReferencesLink to record
Permanent link

Direct link
How Well Do Molecular and Pedigree Relatedness Correspond, in Populations with Diverse Mating Systems, and Various Types and Quantities of Molecular and Demographic Data?
Groningen, The Netherlands.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Groningen, The Netherlands. (IceLab)
Sydney, New South Wales 2052, Australia; Murdoch, WA 6150, Australia.
Groningen, The Netherlands.
2015 (English)In: G3: Genes, Genomes, Genetics, ISSN 2160-1836, Vol. 5, no 9, 1815-1826 p.Article in journal (Refereed) Published
Abstract [en]

Kinship analyses are important pillars of ecological and conservation genetic studies with potentially far-reaching implications. There is a need for power analyses that address a range of possible relationships. Nevertheless, such analyses are rarely applied, and studies that use genetic-data-based-kinship inference often ignore the influence of intrinsic population characteristics. We investigated 11 questions regarding the correct classification rate of dyads to relatedness categories (relatedness category assignments; RCA) using an individual-based model with realistic life history parameters. We investigated the effects of the number of genetic markers; marker type (microsatellite, single nucleotide polymorphism SNP, or both); minor allele frequency; typing error; mating system; and the number of overlapping generations under different demographic conditions. We found that (i) an increasing number of genetic markers increased the correct classification rate of the RCA so that up to >80% first cousins can be correctly assigned; (ii) the minimum number of genetic markers required for assignments with 80 and 95% correct classifications differed between relatedness categories, mating systems, and the number of overlapping generations; (iii) the correct classification rate was improved by adding additional relatedness categories and age and mitochondrial DNA data; and (iv) a combination of microsatellite and single-nucleotide polymorphism data increased the correct classification rate if <800 SNP loci were available. This study shows how intrinsic population characteristics, such as mating system and the number of overlapping generations, life history traits, and genetic marker characteristics, can influence the correct classification rate of an RCA study. Therefore, species-specific power analyses are essential for empirical studies.

Place, publisher, year, edition, pages
2015. Vol. 5, no 9, 1815-1826 p.
Keyword [en]
identity by descent (IBD), relatedness, pedigree reconstruction, relatedness category assignment, trinsic population characteristics
National Category
Earth and Related Environmental Sciences
URN: urn:nbn:se:umu:diva-109369DOI: 10.1534/g3.115.019323ISI: 000360703200003PubMedID: 26134496OAI: diva2:856897
Available from: 2015-09-25 Created: 2015-09-25 Last updated: 2015-09-25Bibliographically approved

Open Access in DiVA

fulltext(1403 kB)51 downloads
File information
File name FULLTEXT01.pdfFile size 1403 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kang, Jungkoo
By organisation
Department of Ecology and Environmental Sciences
In the same journal
G3: Genes, Genomes, Genetics
Earth and Related Environmental Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 51 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 74 hits
ReferencesLink to record
Permanent link

Direct link