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Speech intelligibility in Parkinson's disease patients with zona incerta deep brain stimulation
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.ORCID iD: 0000-0002-7626-2889
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.ORCID iD: 0000-0002-2254-7862
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
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2015 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 5, no 10, e00394Article in journal (Refereed) Published
Abstract [en]

Objectives

To investigate the effects of l-dopa (Levodopa) and cZi-DBS (deep brain stimulation in caudal zona incerta) on spontaneous speech intelligibility in patients with PD (Parkinson's disease).

Materials and Methods

Spontaneous utterances were extracted from anechoic recordings from 11 patients with PD preoperatively (off and on l-dopa medication) and 6 and 12 months post bilateral cZi-DBS operation (off and on stimulation, with simultaneous l-dopa medication). Background noise with an amplitude corresponding to a clinical setting was added to the recordings. Intelligibility was assessed through a transcription task performed by 41 listeners in a randomized and blinded procedure.

Results

A group-level worsening in spontaneous speech intelligibility was observed on cZi stimulation compared to off 6 months postoperatively (8 adverse, 1 positive, 2 no change). Twelve months postoperatively, adverse effects of cZi-DBS were not frequently observed (2 positive, 3 adverse, 6 no change). l-dopa administered preoperatively as part of the evaluation for DBS operation provided the overall best treatment outcome (1 adverse, 4 positive, 6 no change).

Conclusions

cZi-DBS was shown to have smaller negative effects when evaluated from spontaneous speech compared to speech effects reported previously. The previously reported reduction in word-level intelligibility 12 months postoperatively was not transferred to spontaneous speech for most patients. Reduced intelligibility due to cZi stimulation was much more prominent 6 months postoperatively than at 12 months.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015. Vol. 5, no 10, e00394
Keyword [en]
Deep brain stimulation, Levodopa, Parkinson's disease, posterior subthalamic area, spontaneous speech intelligibility, zona incerta
National Category
Other Medical Sciences not elsewhere specified
Research subject
Neurosurgery; Linguistics
Identifiers
URN: urn:nbn:se:umu:diva-109416DOI: 10.1002/brb3.394ISI: 000363423500010OAI: oai:DiVA.org:umu-109416DiVA: diva2:857130
Funder
Swedish Research Council, 2011-2294
Available from: 2015-09-28 Created: 2015-09-28 Last updated: 2017-12-01Bibliographically approved

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Sandström, LindaHägglund, PatriciaJohansson, LouiseBlomstedt, PatricKarlsson, Fredrik
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