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Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Science and Technology, Department of Chemistry. (Computational Life Science Cluster, Umeå University, Umeå, Sweden)
Umeå University, Faculty of Science and Technology, Department of Chemistry. (Computational Life Science Cluster, Umeå University, Umeå, Sweden)
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2015 (English)In: Neurocritical Care, ISSN 1541-6933, E-ISSN 1556-0961, Vol. 23, no 2, 225-232 p.Article in journal (Refereed) Published
Abstract [en]

Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate. Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department UmeAyen University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS). Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point. SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 23, no 2, 225-232 p.
Keyword [en]
Delayed neurological deficit, Myo-inositol, Metabolomics, Subarachnoid hemorrhage, Vasospasm, nous blood
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-109362DOI: 10.1007/s12028-014-0089-2ISI: 000360700700012PubMedID: 25667130OAI: oai:DiVA.org:umu-109362DiVA: diva2:857993
Available from: 2015-09-30 Created: 2015-09-25 Last updated: 2017-12-01Bibliographically approved

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Sjöberg, Rickard L.Bergenheim, TommyMörén, LinaAntti, HenrikLindgren, CeciliaNaredi, SilvanaLindvall, Peter

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Sjöberg, Rickard L.Bergenheim, TommyMörén, LinaAntti, HenrikLindgren, CeciliaNaredi, SilvanaLindvall, Peter
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Clinical NeuroscienceDepartment of ChemistryAnaesthesiology
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