Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC
2010 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 15, no 1, 20-30 p.Article in journal (Refereed) Published
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 μmol GSH g-1 haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
Place, publisher, year, edition, pages
Taylor & Francis, 2010. Vol. 15, no 1, 20-30 p.
Physical activity, lung cancer, biomarkers, molecular epidemiology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:umu:diva-109643DOI: 10.3109/13547500903186452ISI: 000274855400002PubMedID: 20050820OAI: oai:DiVA.org:umu-109643DiVA: diva2:858421