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Design, synthesis and evaluation of novel polypharmacological antichlamydial agents
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2015 (English)In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 101, 595-603 p.Article in journal (Refereed) Published
Abstract [en]

Discovery of new polypharmacological antibacterial agents with multiple modes of actions can be an alternative to combination therapy and also a possibility to slow development of antibiotic resistance. In support to this hypothesis, we synthesized 16 compounds by combining the pharmacophores of Chlamydia trachomatis inhibitors and inhibitors of type III secretion (T3S) in gram-negative bacteria. In this study we have developed salicylidene acylhydrazide sulfonamides (11c & 11d) as new antichlamydial agents that also inhibit T3S in Yersinia pseudotuberculosis.

Place, publisher, year, edition, pages
2015. Vol. 101, 595-603 p.
Keyword [en]
Sulfonamides, Acylhydrazones, Heck coupling, Cyanation, Urea derivatives, Thiourea derivatives, lamydia trachomatis, Chlamydia pneumoniae, Type III secretion system, Antibiotic development
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-109812DOI: 10.1016/j.ejmech.2015.07.019ISI: 000360771900051PubMedID: 26204507OAI: oai:DiVA.org:umu-109812DiVA: diva2:859584
Available from: 2015-10-07 Created: 2015-10-06 Last updated: 2017-12-01Bibliographically approved

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Sunduru, NareshSalin, OlliGylfe, ÅsaElofsson, Mikael
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Department of ChemistryUmeå Centre for Microbial Research (UCMR)Department of Clinical MicrobiologyMolecular Infection Medicine Sweden (MIMS)
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European Journal of Medicinal Chemistry
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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