Design, synthesis and evaluation of novel polypharmacological antichlamydial agents
2015 (English)In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 101, 595-603 p.Article in journal (Refereed) Published
Discovery of new polypharmacological antibacterial agents with multiple modes of actions can be an alternative to combination therapy and also a possibility to slow development of antibiotic resistance. In support to this hypothesis, we synthesized 16 compounds by combining the pharmacophores of Chlamydia trachomatis inhibitors and inhibitors of type III secretion (T3S) in gram-negative bacteria. In this study we have developed salicylidene acylhydrazide sulfonamides (11c & 11d) as new antichlamydial agents that also inhibit T3S in Yersinia pseudotuberculosis.
Place, publisher, year, edition, pages
2015. Vol. 101, 595-603 p.
Sulfonamides, Acylhydrazones, Heck coupling, Cyanation, Urea derivatives, Thiourea derivatives, lamydia trachomatis, Chlamydia pneumoniae, Type III secretion system, Antibiotic development
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:umu:diva-109812DOI: 10.1016/j.ejmech.2015.07.019ISI: 000360771900051PubMedID: 26204507OAI: oai:DiVA.org:umu-109812DiVA: diva2:859584