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Long-Term Persistence of an Anxiolytic Drug (Oxazepam) in a Large Freshwater Lake
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
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2015 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 17, 10406-10412 p.Article in journal (Refereed) Published
Abstract [en]

Production and human consumption of pharmaceuticals result in contamination of surface waters worldwide. Little is known about the long-term (i.e., over decades) fate of pharmaceuticals in aquatic systems. Here, we show that the most prescribed anxiolytic in Sweden (oxazepam) persists in its therapeutic form for several decades after being deposited in a large freshwater lake. By comparing sediment cores collected in 1995 and 2013, we demonstrate that oxazepam inputs from the early 1970s remained in the sediments until sampling in 2013, despite in situ degradation processes and sediment diagenesis. In laboratory and pond experiments, we further reveal that therapeutic forms of oxazepam can persist over several months in cold (5 degrees C) lake water free from UV light. We conclude that oxazepam can persist in lakes over a time scale much longer than previously realized and that levels can build up in lakes due to both a legacy of past inputs and a growing urban population.

Place, publisher, year, edition, pages
2015. Vol. 49, no 17, 10406-10412 p.
Keyword [en]
pharmaceuticals, environment, waste-water, pharmaceuticals
National Category
Ecology
Identifiers
URN: urn:nbn:se:umu:diva-109802DOI: 10.1021/acs.est.5b01968ISI: 000360773600017PubMedID: 26196259OAI: oai:DiVA.org:umu-109802DiVA: diva2:859680
Available from: 2015-10-08 Created: 2015-10-06 Last updated: 2017-12-01Bibliographically approved

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Klaminder, JonatanBrodin, TomasSundelin, AnnaFahlman, J.Jonsson, M.Fick, Jerker
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Department of Ecology and Environmental SciencesDepartment of Chemistry
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CiteExportLink to record
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  • apa
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  • de-DE
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  • en-US
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  • nn-NO
  • nn-NB
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  • Other locale
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