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The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
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2015 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 10, no 8, e0135991Article in journal (Refereed) Published
Abstract [en]

High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

Place, publisher, year, edition, pages
2015. Vol. 10, no 8, e0135991
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-109456DOI: 10.1371/journal.pone.0135991ISI: 000360018600095PubMedID: 26287733OAI: diva2:859689
Available from: 2015-10-08 Created: 2015-09-28 Last updated: 2015-10-08Bibliographically approved

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