umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
The specificity of the WINROP algorithm can be significantly increased by reassessment of the WINROP alarm
Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.ORCID iD: 0000-0002-4649-0653
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Show others and affiliations
2015 (English)In: Neonatology, ISSN 1661-7800, E-ISSN 1661-7819, Vol. 108, no 2, 152-156 p.Article in journal (Refereed) Published
Abstract [en]

Background: Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinations in these infants.

Objectives: To improve the specificity of the WINROP (Weight, Insulin-like growth factor-I, Neonatal, ROP) surveillance system, identifying extremely preterm infants requiring treatment for ROP.

Methods: Two cohorts that had previously been subjected to WINROP analyses were included and reevaluated in this study. The weight at WINROP alarm for extremely preterm infants, born at gestational age <27 weeks, was reevaluated and by establishing 'safe' WINROP alarm weight limits, an intersample reassessment of WINROP alarm was performed. The two cohorts were as follows: (1) the Extremely Preterm Infants in Sweden Study (EXPRESS) cohort, infants born in Sweden during 2004-2007 (n = 407), and (2) extremely preterm infants in a North American co-hort, born during 2006-2009 (n = 566).

Results: In the EXPRESS cohort, 12.5% (40/319) of the infants who previously received a WINROP alarm were now reassessed as having no alarm; the specificity of WINROP in EXPRESS increased from 23.9% (86/360) to 35.0% (126/360). In the North American cohort, 15.4% (81/526) were reassessed as having no alarm; the specificity increased from 8.5% (38/447) to 26.6% (119/447). The sensitivity persisted as 97.5% in EXPRESS (45/47) and 98.3% (117/119) in the North American cohort.

Conclusions: The specificity of the WINROP surveillance system for extremely preterm infants can be significantly improved by reassessment using the weight at WINROP alarm.

Place, publisher, year, edition, pages
S. Karger, 2015. Vol. 108, no 2, 152-156 p.
Keyword [en]
Retinopathy of prematurity, Extremely preterm, WINROP system
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-110219DOI: 10.1159/000435770ISI: 000361829500003PubMedID: 26159370OAI: oai:DiVA.org:umu-110219DiVA: diva2:861351
Available from: 2015-10-16 Created: 2015-10-16 Last updated: 2016-01-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Stoltz Sjöström, ElisabethDomellöf, Magnus
By organisation
Department of Food and NutritionPaediatrics
In the same journal
Neonatology
Pediatrics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link