umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of prostaglandin E2 (PGE2) and drugs affecting PGE2 degradation on acute rejection of rat cardiac allografts
1992 (English)In: Scand J Thorac Cardiovasc Surg, Vol. 26, no 1, 33-7 p.Article in journal (Refereed) Published
Abstract [en]

Systemic administration of prostaglandin E2 (PgE2) has been reported to prolong graft survival of heart transplants. We investigated the influence of systemic injection of two compounds which inhibit the endogenous degradation of PgE2 (CL42A and CL68A) and of local infusion of PgE2 into the transplant on the survival time of rat cardiac allografts. Both CL42A and CL68A gave increased graft survival time in two rat strain combinations, though this was not predictable in individual rats. Locally infused PgE2 gave slight, but not significant prolongation of graft survival in some recipients. Combined PgE2 and cyclosporin A, however, gave significant prolongation of graft survival time compared with cyclosporin A treatment alone. When local PgE2 treatment was begun 5 days after transplantation, graft survival time was prolonged in almost all the rats. Manipulation of the local PgE2 concentration thus seemed to have a positive effect on graft survival, possibly due to down-regulation of certain cells of the immune system by PgE2.

Place, publisher, year, edition, pages
1992. Vol. 26, no 1, 33-7 p.
Keyword [en]
Acute Disease, Animals, Benzophenones/*pharmacology, Cyclosporine/pharmacology, Dinoprostone/metabolism/*pharmacology, Graft Rejection/*drug effects, Graft Survival/*drug effects, *Heart Transplantation, Male, Propiophenones/*pharmacology, Rats, Rats, Inbred Strains, Rats, Inbred WKY
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:umu:diva-110948ISBN: 0036-5580 (Print) 0036-5580 (Linking) OAI: oai:DiVA.org:umu-110948DiVA: diva2:865826
Note

Wanders, A Tufveson, G Gerdin, B eng Research Support, Non-U.S. Gov't SWEDEN 1992/01/01 Scand J Thorac Cardiovasc Surg. 1992;26(1):33-7.

Available from: 2015-10-29 Created: 2015-10-29 Last updated: 2015-10-29

Open Access in DiVA

No full text

Other links

http://www.ncbi.nlm.nih.gov/pubmed/1529295

Search in DiVA

By author/editor
Wanders, A.
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar

Total: 16 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf