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Effect of LS-2616 on the graft protection achieved by cyclosporin A, prednisolone, and 15-deoxyspergualin in heart-transplanted rats
1992 (English)In: Transpl Int, Vol. 5 Suppl 1, S462-3 p.Article in journal (Refereed) Published
Abstract [en]

The immunostimulator LS-2616 abolishes the effect of cyclosporin A in a rat cardiac transplantation model. The present paper compares the characteristics of rejection obtained under different immunosuppressive regimens with and without additional LS-2616 application in the same model. Cyclosporin A (CyA, 10 mg/kg daily), prednisolone (15 mg/kg daily), or 15-deoxyspergualin (2, 5, or 10 mg/kg daily), all given from the day of transplantation until day 9, protected the grafts during the treatment period. The addition of LS-2616 (160 mg/kg, day -1 until stop) resulted in a total abrogation of the immunosuppressive effect of CyA and prednisolone. However, LS-2616 could only partially or not at all reverse the effect of 15-deoxyspergualine. These results show a certain drug selectivity of LS-2616 in promoting rejection of immunosuppressed allografts. Further studies with LS-2616 may be of benefit in evaluating the mode of action of different immunosuppressive compounds and, thus, contribute to finding more effective antirejection therapies.

Place, publisher, year, edition, pages
1992. Vol. 5 Suppl 1, S462-3 p.
Keyword [en]
Adjuvants, Immunologic/*therapeutic use, Animals, Cyclosporine/*therapeutic use, Graft Survival/drug effects/*immunology, Guanidines/*therapeutic use, Heart Transplantation/*immunology, Hydroxyquinolines/*therapeutic use, Immunosuppressive Agents/therapeutic use, Models, Animal, Prednisolone/*therapeutic use, Rats, Rats, Inbred Strains, Rats, Inbred WKY, Time Factors
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:umu:diva-110941ISBN: 0934-0874 (Print) 0934-0874 (Linking)OAI: oai:DiVA.org:umu-110941DiVA: diva2:865837
Note

Wanders, A Gannedahl, G Gerdin, B Tufveson, G eng Germany 1992/01/01 00:00 Transpl Int. 1992;5 Suppl 1:S462-3.

Available from: 2015-10-29 Created: 2015-10-29 Last updated: 2015-10-29

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http://www.ncbi.nlm.nih.gov/pubmed/14621847

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