umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Effects of angiopeptin on transplant arteriosclerosis in the rat
Show others and affiliations
1995 (English)In: Transpl Int, Vol. 8, no 2, 103-10 p.Article in journal (Refereed) Published
Abstract [en]

The influence of the somatostatin analogue angiopeptin on transplant arteriosclerosis was investigated using two aortic transplantation rat models. One was characterized by ischemia/reperfusion-induced changes in syngeneic transplants while immunologically induced changes dominated in the other allogeneic model. Angiopeptin, 100 micrograms/kg per day, was administered continuously until the sacrifice of the rats after 8 weeks. No additional immunosuppression was used in either model. An image analysis system was used to quantify the intimal and medial thicknesses of the grafts. In the syngeneic grafts, the intimal thickness was less than 50% of that of control grafts (P < 0.05), but no difference was seen in the allogeneic model. The expression of selected cells, TGF-beta s, and PDGF and PDGF alpha-receptors was detected immunohistochemically and displayed a similar picture in control and angiopeptin-treated grafts in both models. We conclude that angiopeptin has no clear immunosuppressive properties but may counteract ischemia-induced transplant arteriosclerosis.

Place, publisher, year, edition, pages
1995. Vol. 8, no 2, 103-10 p.
Keyword [en]
Animals, Aorta/*transplantation, Arteriosclerosis/*drug therapy/etiology, Image Processing, Computer-Assisted, Male, Oligopeptides/*pharmacology, Platelet-Derived Growth Factor/analysis, Rats, Reperfusion Injury/*complications, Somatostatin/*analogs & derivatives/pharmacology, Transforming Growth Factor beta/analysis, Transplantation, Homologous/pathology, Transplantation, Isogeneic/pathology, Tunica Intima/pathology, Tunica Media/pathology
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:umu:diva-110895ISBN: 0934-0874 (Print) 0934-0874 (Linking)OAI: oai:DiVA.org:umu-110895DiVA: diva2:865896
Note

Akyurek, M L Wanders, A Aurivillius, M Larsson, E Funa, K Fellstrom, B C eng Research Support, Non-U.S. Gov't GERMANY 1995/01/01 Transpl Int. 1995;8(2):103-10.

Available from: 2015-10-29 Created: 2015-10-29 Last updated: 2015-10-29

Open Access in DiVA

No full text

Other links

http://www.ncbi.nlm.nih.gov/pubmed/7766291

Search in DiVA

By author/editor
Wanders, A.
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link