Change search
ReferencesLink to record
Permanent link

Direct link
Prevalence and risk factors of COPD among never-smokers in two areas of Sweden: Occupational exposure to gas, dust or fumes is an important risk factor
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. Obstructive Lung Disease In Northern Sweden (OLIN) Studies, Norrbotten County Council, Luleå, Sweden.
Show others and affiliations
2015 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 109, no 11, 1439-1445 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Although active tobacco smoking is the main risk factor for COPD, COPD is not uncommon also among never-smokers. Different study locations along with different spirometric definitions of COPD have historically yielded different prevalence estimates of the disease.

AIM: To study current prevalence and risk factors of COPD among never-smokers in two areas of Sweden.

METHODS: Data collected in 2008-2012 within the West Sweden Asthma Study and Obstructive Lung Disease in Northern Sweden Studies was pooled. The study population consisted of 1839 subjects who participated in spirometry and interviews. COPD was defined as post-bronchodilator a) FEV1/(F)VC < 0.7, b) FEV1/FVC < 0.7 and c) FEV1/FVC < lower limit of normal.

RESULTS: Of the 1839 subjects, 967 (52.6%) were never-smokers. Among the never-smoking subjects, the prevalence of COPD according to definitions a-c was 7.7%, 4.9% and 3.0%, respectively. The corresponding prevalence of GOLD grade ≥2 was 2.0%, 1.4% and 1.3%. No significant difference in prevalence between the two study areas was observed. In never-smokers, occupational exposure to gas, dust or fumes (GDF) was significantly associated with both COPD (OR 1.85, 95% CI 1.03-3.33), and GOLD ≥2 (OR 4.51, 1.72-11.9) according to definition a), after adjusting for age, educational level and exposure to passive smoking at work.

CONCLUSION: Depending on definition, prevalence of COPD among never-smokers was 3.0-7.7%, whereas GOLD ≥2 was present in 1.3-2.0%. Occupational exposure to GDF remained independently and significantly associated with COPD regardless of spirometric definition of the disease.

Place, publisher, year, edition, pages
2015. Vol. 109, no 11, 1439-1445 p.
Keyword [en]
COPD, Never smokers, Epidemiology, Population study, Risk factors
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cardiac and Cardiovascular Systems Respiratory Medicine and Allergy
URN: urn:nbn:se:umu:diva-111246DOI: 10.1016/j.rmed.2015.09.012ISI: 000364820800010PubMedID: 26440676OAI: diva2:868763
Available from: 2015-11-11 Created: 2015-11-11 Last updated: 2016-03-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Backman, HelenaBjerg, AndersHedman, LinneaLindberg, AnneRönmark, Eva
By organisation
Occupational and Environmental MedicinePulmonary Medicine
In the same journal
Respiratory Medicine
Public Health, Global Health, Social Medicine and EpidemiologyCardiac and Cardiovascular SystemsRespiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link