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The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption.
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2007 (English)In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 102, no 3Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents.

DESIGN, SETTING AND PARTICIPANTS: A cross-sectional study of a randomized sample of 66 male individuals from a total population of 16- and 19-year adolescents from a Swedish county. Boys, who volunteered to participate answering an alcohol-related problem/behaviour questionnaire, were investigated with regard to interactions between such problems, family function, maltreatment and MAO-A genotype.

MEASUREMENTS: MAO-A genotype, family relations history, history of being maltreated or abused and alcohol-related problem behaviour.

FINDINGS: Boys with the short (three-repeat) variant of the MAO-A gene, who had been maltreated/abused or came from families with poor relations, showed significantly higher scores of alcohol-related problems. We also found that maltreatment/abuse independently showed the strongest relation to alcohol-related problems among boys in our model.

CONCLUSIONS: The results suggest that both maltreatment and MAO-A genotype may be useful for the understanding of male adolescent alcohol-related problem behaviour.

Place, publisher, year, edition, pages
2007. Vol. 102, no 3
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-111358DOI: 10.1111/j.1360-0443.2006.01702.xPubMedID: 17298646OAI: oai:DiVA.org:umu-111358DiVA: diva2:869429
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2015-11-13

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Citation style
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