Change search
ReferencesLink to record
Permanent link

Direct link
Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.
Show others and affiliations
2009 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 116, no 3Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate possible interactions between the gene coding for activating protein-2 beta (AP-2 beta) and psychosocial factors to predict depressive symptoms in adolescents. Two-hundred 16- and 19-year-old adolescents from the county of Västmanland, Sweden, were asked to complete a questionnaire, interviewed about psychosocial risk factors, and genotyped with regard to the transcription factor AP-2 beta intron 2 polymorphism. AP-2 beta genotype interacted significantly both with type of housing and parental separation to predict depressive symptoms. Individuals who were homozygous for the short AP-2 beta allele displayed higher depression scores when psychosocial adversity was taken into account. Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments.

Place, publisher, year, edition, pages
2009. Vol. 116, no 3
National Category
URN: urn:nbn:se:umu:diva-111335DOI: 10.1007/s00702-009-0183-3PubMedID: 19184334OAI: diva2:869441
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2015-11-13

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sjöberg, Rickard L
In the same journal
Journal of neural transmission

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link