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WHO guidelines for a healthy diet and mortality from cardiovascular disease in European and American elderly: the CHANCES project
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2015 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 102, no 4, 745-756 p.Article in journal (Refereed) Published
Abstract [en]

Background: Cardiovascular disease (CVD) represents a leading cause of mortality worldwide, especially in the elderly. Lowering the number of CVD deaths requires preventive strategies targeted on the elderly. Objective: The objective was to generate evidence on the association between WHO dietary recommendations and mortality from CVD, coronary artery disease (CAD), and stroke in the elderly aged >= 60 y. Design: We analyzed data from 10 prospective cohort studies from Europe and the United States comprising a total sample of 281,874 men and women free from chronic diseases at baseline. Components of the Healthy Diet Indicator (HDI) included saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, dietary fiber, and fruit and vegetables. Cohort-specific HRs adjusted for sex, education, smoking, physical activity, and energy and alcohol intakes were pooled by using a random-effects model. Results: During 3,322,768 person-years of follow-up, 12,492 people died of CVD. An increase of 10 HDI points (complete adherence to an additional WHO guideline) was, on average, not associated with CVD mortality (HR: 0.94; 95% CI: 0.86, 1.03), CAD mortality (HR: 0.99; 95% CI: 0.85, 1.14), or stroke mortality (HR: 0.95; 95% CI: 0.88, 1.03). However, after stratification of the data by geographic region, adherence to the HDI was associated with reduced CVD mortality in the southern European cohorts (HR: 0.87; 95% CI: 0.79, 0.96; I2 = 0%) and in the US cohort (HR: 0.85; 95% CI: 0.83, 0.87; I2 = not applicable). Conclusion: Overall, greater adherence to the WHO dietary guidelines was not significantly associated with CVD mortality, but the results varied across regions. Clear inverse associations were observed in elderly populations in southein Europe and the United States.

Place, publisher, year, edition, pages
2015. Vol. 102, no 4, 745-756 p.
Keyword [en]
aging, CHANCES, cardiovascular disease, cohort, meta-analysis, GROOT LCPGM, 1991, EUROPEAN JOURNAL OF CLINICAL NUTRITION, V45, P23 asey Anne, 2006, BMC PUBLIC HEALTH, V6, urlouki Eleni, 2009, CLINICAL INTERVENTIONS IN AGING, V4, P319 rrari Pietro, 2008, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, V37, P368
National Category
Nutrition and Dietetics Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-111001DOI: 10.3945/ajcn.114.095117ISI: 000362241900006PubMedID: 26354545OAI: diva2:871804
Available from: 2015-11-17 Created: 2015-11-02 Last updated: 2016-02-11Bibliographically approved

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Wennberg, Maria
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Nutritional Research
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