Responses of mammalian cells to mechanical forces
2001 (English)In: Recent Research Developments in Biophysics and Biochemistry / [ed] Pandalai, S. G., Trivandrum, India: Research Signpost , 2001, Vol. 1, 77-89 p.Chapter in book (Other academic)
All cells and tissues of our body are continuously subject to various mechanical stresses. These forces include, e.g., compression, shear stress, hydrostatic pressure and osmotic pressure. The range of forces vary from few pascals to several megapascals in magnitude. In many cases, mechanical forces are required for the tissues to maintain their normal functional structure and composition. However, excessive forces in the end may lead to adverse responses. In this paper, we review the data available from many different tissues in order to compare the signaling mechanisms involved in cellular mechanotransduction, and how the cells respond to forces that are too strenuous for them to withstand. The possible stress reactions caused by excessive forces are also discussed.
Place, publisher, year, edition, pages
Trivandrum, India: Research Signpost , 2001, Vol. 1. 77-89 p.
Biophysics, Mechanobiology, Cell
Cell and Molecular Biology Biochemistry and Molecular Biology Biophysics
Research subject Biochemistry; cellforskning; biomechanics
IdentifiersURN: urn:nbn:se:umu:diva-111584ISBN: 81-7736-057-4OAI: oai:DiVA.org:umu-111584DiVA: diva2:871917