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Self-reported memory failures: associations with future dementia in a population-based study with long-term follow-up
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Social Sciences, Department of Psychology. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0001-9785-8473
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
2015 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 63, no 9, 1766-1773 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To examine the association between self-reported memory failures and incident dementia in individuals aged 60 and older.

DESIGN: Longitudinal, community based.

SETTING: Betula Prospective Cohort Study, a population-based study in Umea, Sweden.

PARTICIPANTS: Individuals with a mean age of 71.5 +/- 8.8 (range 60-90) (N = 1,547).

MEASUREMENTS: Participants rated the frequency of everyday memory failures using the 16-item Prospective and Retrospective Memory Questionnaire (PRMQ) and underwent objective memory testing at baseline. Participant self-reports of complaints of poor memory by family and friends were evaluated. Dementia status was followed-up for 10 to 12 years.

RESULTS: Over the study period, 225 participants developed dementia (132 with Alzheimer's disease (AD)). In Cox proportional hazard regression models adjusted for demographic factors, PRMQ z-scores predicted incident dementia (hazard ratio (HR) = 1.21 for all-cause dementia; HR = 1.25 for AD, Ps < .01). The significant associations remained when depressive symptoms and objective memory performance were adjusted for, when low performers on objective memory (= 1 standard deviations below the age group mean) were excluded, and in analyses with delayed entry (survival time = 5 years). Similar patterns were observed for the prospective and retrospective subscales, although including how often participants self-reported that others complained about their poor memory eliminated the association between PRMQ scores and dementia and itself emerged as a significant predictor.

CONCLUSION: Self-reported memory failure predicted future dementia or AD independent of objective memory performance. Subjective reports of complaints by family and friends appear to be an even more-important indicator of preclinical impairments, and physicians should not ignore them, even in the absence of objective memory deficits.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 63, no 9, 1766-1773 p.
Keyword [en]
subjective memory, objective memory, dementia, Alzheimer's disease
National Category
Public Health, Global Health, Social Medicine and Epidemiology Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-111769DOI: 10.1111/jgs.13611ISI: 000363804800005PubMedID: 26280989ScopusID: 2-s2.0-84942197349OAI: oai:DiVA.org:umu-111769DiVA: diva2:873667
Available from: 2015-11-24 Created: 2015-11-23 Last updated: 2016-03-22Bibliographically approved

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Rönnlund, MichaelSundström, AnnaAdolfsson, RolfNilsson, Lars-Göran
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Department of PsychologyCentre for Demographic and Ageing Research (CEDAR)PsychiatryUmeå Centre for Functional Brain Imaging (UFBI)
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Journal of The American Geriatrics Society
Public Health, Global Health, Social Medicine and EpidemiologyGeriatrics

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