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Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, 1104-1108 p.Article in journal (Refereed) Published
Abstract [en]

AimPulmonary hypertension has been linked to premature birth, chronic lung disease, bronchopulmonary dysplasia and congenital heart disease. This national population-based registry study assessed the risk of adult pulmonary hypertension following premature birth, adjusted for known risk factors. MethodsWe focused on adults in the Swedish Pulmonary Arterial Hypertension Registry, who were born prematurely, and controls randomly selected from the Swedish medical birth register and matched to each case by birth year and delivery hospital. Information on perinatal factors was also retrieved from the medical birth register. Conditional multiple logistic regression was used to evaluate the association between premature birth and adult pulmonary hypertension, taking into account the potential confounding factors. ResultsThe study population comprised 427 adults born between 1973 and 1996, with 61 cases and 366 controls. Adult pulmonary hypertension was associated with premature birth, with an odds ratio of 3.08 and 95% confidence interval of 1.21-7.87. The association did not alter after adjusting for potential confounders. ConclusionBy adjusting for factors linked to adult pulmonary hypertension, namely congenital heart defects, pulmonary diseases and premature birth, we were able to show that other unknown factors may influence the risk for pulmonary hypertension among adults who were born premature.

Place, publisher, year, edition, pages
2015. Vol. 104, no 11, 1104-1108 p.
Keyword [en]
Brochopulmonary dysplasia, Chronic lung disease, Premature birth, Pulmonary Hypertension, Risk ctors
National Category
Clinical Medicine
URN: urn:nbn:se:umu:diva-111757DOI: 10.1111/apa.13205ISI: 000363866200023PubMedID: 26346500ScopusID: 2-s2.0-84945162469OAI: diva2:874102
Available from: 2015-11-25 Created: 2015-11-23 Last updated: 2016-06-29Bibliographically approved

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